More facts about Circadian Sleep

Aging, hectic modern lifestyles and other factors can disrupt our circadian clocks, which can affect our health.^1-3 So we developed our Circadian Sleep formula to restore these natural rhythms: MicroActive® Melatonin supports the central clock in the brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of the body.

Melatonin for healthy sleep-wake cycling

Peripheral circadian clocks exist in virtually every cell of our bodies and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.⁴ Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland.⁵ Melatonin ensures that the central clock is properly supporting sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.

The first step to healthy, whole-body circadian rhythms is to restore that central clock with melatonin.

Nobiletin for healthy peripheral circadian rhythms

Peripheral circadian clocks in various organs govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function and more.^6-8 Nobiletin is a polymethoxylated flavone isolated from young citrus peel. Results from a recent pre-clinical study suggest that nobiletin may also help positively support peripheral circadian rhythms.⁹ It does so by directly activating a unique set of receptors widely expressed throughout the body and known to play a key role in supporting circadian rhythms.^10-14 It has also been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.¹⁵

Nobiletin promotes whole-body health

In another pre-clinical study, nobiletin supports the expression of circadian genes which themselves control the expression of other genes with specific circadian functions in every cell.¹⁶ Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver and kidney health and also helps maintain healthy blood pressure, cholesterol and triglyceride levels already within the normal range.^17-20

Innovative circadian health formula

By supporting both “central” and “peripheral” circadian clocks, our Circadian Sleep represents an innovative, restorative approach to whole-body health. Try Circadian Sleep today!