Estrogen Supplements: How Do They Work?

Estrogen is one of those hormones that are vital for your well-being. However, age-related hormonal changes during perimenopause and menopause significantly impact our levels of this essential sex hormone. As if dealing with those monthly cyclical changes when we were younger wasn't enough (yes, we mean you, menstrual cycle!).

While hormonal changes are a natural part of our ever-changing physiologies, that doesn't mean experiencing a decline in estrogen is a picnic. There's nothing fun about feeling fatigued by the end of the day or pesky night sweats while you're trying to get some shuteye, not to mention mood swings, hot flashes and just feeling off. And forget about bedroom fun when you're dealing with vaginal discomfort.

Fortunately, women who want to maintain a healthy hormone balance have options, including vitamins and products sometimes labeled estrogen supplements that can help. But what we call "estrogen supplements" don't contain estrogen per se. Yes, that's a little confusing, but we'll explain in more detail as you keep reading.

So, wondering whether there's a vitamin or supplement that boosts healthy estrogen levels? We asked Life Extension's Education Scientist, Dr. Vanessa Pavey, ND, for the lowdown on how estrogen-supporting supplements work and what you can do to help with the inevitable hormonal transitions.

What is estrogen?

Estrogen is a class of steroid hormones (progesterone is another one) made by both women and men, explained Dr. Pavey. For women, its primary role is in supporting reproductive health. The body produces three main estrogens. Each form tends to be more dominant at different phases of a woman's life:

1. Estradiol—

   This steroid hormone is the most potent form of estrogen produced by the ovaries. It helps regulate the menstrual cycle.

2. Estriol—

   Estriol is the body's main form of estrogen during pregnancy.

3. Estrone—

   This is the main form of estrogen during menopause, and it's mainly produced by fat cells.

While, indeed, estrogen is a key player in sexual and reproductive health (including libido), this hormone has other roles, too, including influencing bone health, cognitive and cardiovascular health, breast health, mood and more.

How does aging affect your estrogen levels?

The ovaries produce less estrogen as we age, which typically begins as you approach your 40s. "Women may notice their menstrual cycles become longer or shorter and more or less frequent due to changes in hormone levels," explained Dr. Pavey.

Eventually, these changes usher in perimenopause and then menopause. Skipping periods or irregular periods are common perimenopause markers. And menopause happens when there hasn't been a period for 12 months. During these transitions, women may experience other discomforts like hot flashes, vaginal dryness and night sweats.

This hormonal transition leaves post-menopausal women with low estrogen, which can also impact bone health, weight, mood, cognition and cardiovascular health. That's why it's crucial to learn about your body and find ways you can complement your diet with vitamins and nutrients that support optimal well-being at any age.

Pro tip: If you're concerned about vitamin D deficiency associated with low estrogen, speak with your doctor about adding vitamin D to your supplement regimen. It can help support your bones, cognition, immune health and more. Healthy vitamin D levels are especially important for menopausal and post-menopausal women.

Do supplements increase estrogen levels?

No, estrogen supplements don't increase estrogen production in the ovaries, explained Dr. Pavey. But supplementation of the right vitamin or nutrient can complement an estrogen-friendly lifestyle.

Estrogen supplements supply the body with nutrients like soy isoflavones; or indole-3-carbinol from cruciferous vegetables, which supports normal estrogen metabolism—but remember that estrogen supplements don't contain estrogen. What does metabolism have to do with these sex hormones? This cascade of biological events is how your body maintains homeostasis, the natural state of equilibrium from head-to-toe and inside out, including balanced hormone levels.

9 nutrients for healthy estrogen levels

You can help relieve menopausal symptoms (as well as perimenopause) by incorporating the following nine estrogen-balancing nutrients and can help keep estrogen and progesterone metabolism healthy.

1. Flax seeds—This superfood is a terrific dietary source of lignans. These types of well-studied phytoestrogens have antioxidant properties and help relieve menopause-related discomforts.

2. Soy—

   This meat alternative offers one of the best-studied isoflavones, explained Dr. Pavey. Soy is a rich source of isoflavones, dietary phytoestrogens that can bind to the estrogen receptors and help relieve menopausal discomforts. Supplements containing the isoflavone genistein have been shown to help ease hot flashes.

3. Siberian rhubarb

   —You'll find this nutrient as an extract in menopause supplements. This root extract can be a terrific alternative to soy products that also help alleviate menopause-related symptoms. "Its active components have an attraction for the beta estrogen receptors, and it could explain why it provides up to 83% reduction in total menopausal discomforts," explained Dr. Pavey.

4. Vitamin B6

   —Your B-complex vitamins are essential to overall health, but to support your mood, especially during menopause, you want B6. While this vitamin won't "boost" your estrogen levels, it has been shown to combat the effects of high estrogen. "Out of all the B vitamins, B6 is essential to producing serotonin, one of your "feel-good" neurotransmitters. Estrogen may affect serotonin levels because it's involved in the production and breakdown of this brain chemical," noted Dr. Pavey.

Pro tip: Your body needs the active form of B6. Although your body can convert inactive vitamin B6 to its active form, you can find supplements that deliver biologically active B6.

5. Broccoli extract

   —Cruciferous vegetables like broccoli, Brussels sprouts, cauliflower, and cabbage are rich sources of indole-3-carnbinol. Your body converts I3C into diindolylmethane (DIM), another critical compound for healthy estrogen metabolism. Broccoli extracts that contain DIM and I3C help promote the formation of more "good" estrogen compounds instead of the less favorable ones, explained Dr. Pavey.

6. Chasteberry

   —Also known as Vitex agnus-castus, chasteberry contains compounds that can help ease menopausal discomforts, explained Dr. Pavey.

7. Boron

   —This essential mineral is needed only in small amounts. Still, boron is essential for estrogen and vitamin D metabolism, bone health, and magnesium absorption. Low estrogen can impact bone health, increasing the risk for bone density loss. "During menopause, women need to be more vigilant about bone health. And boron is a trace mineral that can be overlooked," added Dr. Pavey.

8. Dong quai

   —Known by its scientific name Angelica sinensis, this herb is commonly used to ease menopause-related symptoms.

9. Red clover

   —This is another excellent source of isoflavones. It has a long history of supporting women's health. Some studies have shown that red clover extract can support bone health in premenopausal and menopausal women.

How do estrogen supplements work?

In a nutshell, what we call "estrogen supplements" don't actually contain estrogen; instead, they offer specific nutrients that can have an estrogen-like effect on your body. Let's break this down:

• Cell communication:

  First, let's go over how your cells work. Your body has an intricate biological mechanism that allows it to interact with the variety of proteins and hormones in our bodies, as well as the nutrients and compounds from our foods to support biological processes. Every cell (be it a skin, liver, brain, stomach, or reproductive tissue cell) has receptors on its surface that can bind to specific compounds. Each receptor has a compound-specific shape, so both the receptor and compound fit together like puzzle pieces.

• Estrogen receptors

  : These receptors have a strong attraction for, you guessed it, estrogen. As Dr. Pavey explained, there are two types of estrogen receptors: alpha and beta, and each is predominant in different tissues. Alpha estrogen receptors are primarily found in reproductive tissues (think breasts, ovaries and uterus). In contrast, beta estrogen receptors are found in non-reproductive tissues like bone, skin, blood vessels and brain. "Activating beta estrogen receptors in peripheral tissues can help promote beneficial effects on these organs and can help relieve menopausal symptoms," added Dr. Pavey.

• Phytoestrogens

  : Your body's estrogen receptors are also attracted to phytoestrogens, naturally occurring compounds found in certain plants (and as extracts in supplements). Phytoestrogens can bind to your cells' estrogen receptors and can exert an estrogen-like effect on the body. But their effect is weaker than human hormones or concentrated hormone products.

So while estrogen supplements don't contain estrogen, the phytoestrogen nutrients in them can trigger a similar impact on your body as actual estrogen. "The biochemical effect of phytoestrogens is weaker than the actual estradiol hormone; still, nutrients supplied in estrogen supplements can help relieve common menopausal symptoms," Dr. Pavey explained.

Pro tip: If you have a history of estrogen-dependent health concerns, or are being treated for low estrogen, speak with your doctor before consuming phytoestrogens.

5 life hacks to support healthy estrogen levels

You can help your body support hormone balance by building sustainable daily habits—when you focus on supporting overall wellness, your hormone health may follow! Plus, adding vitamins and other dietary supplementation can help guard against any deficiency that could be present in your diet.

Don't know where to start? Here are five ways you can help your body promote hormone balance.

1. Keep moving—

   The whole-body health benefits of exercise are undeniable, and they go beyond lean muscle mass or even a brain boost. Incorporating a regular exercise routine into your days can keep your hormones balanced and potentially help improve menopause-related complaints.

2. Manage stress—

   It's no secret that unmanaged stress can take a toll on your overall health. That overload of cortisol can impact menopause-related discomforts like hot flashes. You can learn strategies that help you calm yourself and stay "cool" when facing daily stress.

3. Eat phytoestrogen-rich foods—

   Incorporating isoflavones-rich foods like soy and flax seeds into your meals can help support estrogen balance. 
   Pro tip: When possible, buy organic or non-GMO foods. These food items follow strict guidelines that ensure the products you're consuming don't have added hormones or antibiotics that can impact your hormone balance.

4. Don't forget your cruciferous vegetables—

   Veggies like broccoli, cabbage, kale, and cauliflower provide compounds like indole-3-carnbinol that can help support healthy estrogen metabolism.

5. Connect with your body—

   Learn to recognize discomforts as ways in which your body communicates with you, letting you know that there's something you need to address in your metabolism. Maybe it's a vitamin D deficiency, or perhaps it's estrogen dominance (where there's high estrogen in relation to progesterone). Picking up on the discomforts you're experiencing allows you to make changes (in your diet or daily habits) that can significantly improve your quality of life.

The best “you” is yet to come

Granted, it's not easy to be enthusiastic about the changes of menopause. But, as our bodies find balance throughout the hormonal readjustment, we can learn to embrace the changes that perimenopause and menopause bring—whether it's laugh lines that come from a thoroughly enjoyed life, a mane of shining gray, or well-earned wisdom. With a healthy lifestyle, thoughtful nutrition, and a great relationship with your healthcare provider, you can emerge from this inevitable life transition into a stronger, more confident woman.

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